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Synaptic and extrasynaptic neurotransmitter receptors in glial precursors' quest for identity
Author(s) -
Belachew Shibeshih,
Gallo Vittorio
Publication year - 2004
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.20077
Subject(s) - neuroscience , biology , neurotransmitter receptor , neurotransmitter , receptor , neuroblast , neuron , glutamate receptor , neurotransmitter agents , neuroglia , neural stem cell , progenitor cell , central nervous system , neurogenesis , stem cell , microbiology and biotechnology , biochemistry
It is widely established that neurotransmitter receptors are expressed in non‐neuronal cells, and particularly in neural progenitor cells in the postnatal central nervous system. The functional role of these receptors during development is unclear, but it needs to be revisited now that cells previously considered restricted to glial lineages have been shown to generate neurons. The present review integrates recent advances, to shed new light on how neurotransmitter receptors may, alternatively, serve as excitable mediators of neuron‐glia and neuron‐neuroblast interactions. © 2004 Wiley‐Liss, Inc.