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Glyt‐1 expression in cultured human Müller cells and intact retinae
Author(s) -
Reye Peter,
Penfold Philip,
Pow David V.
Publication year - 2001
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.1064
Subject(s) - biology , immunocytochemistry , neuroscience , microbiology and biotechnology , in vitro , in vivo , pathophysiology , endocrinology , biochemistry , genetics
In this study, we demonstrate that Müller cells cultured from human retinas are capable of strongly expressing the glycine transporter Glyt‐1 as assessed by immunocytochemistry. By contrast, intact normal and pathological human retinas exhibit Glyt‐1 immunoreactivity only in neurons. These data suggest that Glyt‐1 expression in cultured Müller cells is an epiphenomenon associated with culturing in vitro, rather than a normal physiological or even pathophysiological phenomenon in vivo. GLIA 34:311–315, 2001. © 2001 Wiley‐Liss, Inc.