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Region‐specific effects of glia on neuronal induction and differentiation with a focus on dopaminergic neurons
Author(s) -
Hall Anita C.,
Mira Helena,
Wagner Joseph,
Arenas Ernest
Publication year - 2003
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.10229
Subject(s) - neuroblast , biology , neuroscience , neuron , phenotype , nervous system , cell type , cell , neurogenesis , genetics , gene
Radial glia (RG) are the first glial cell type to appear in the nervous system. Their broad distribution and apparent similarity hide important brain region‐specific differences that are likely to be essential for development. However, recent evidence supports the stimulating concept that in addition to their classical function as neuroblast guides, RG are neuronal precursors (Malatesta et al. Development 127:5253–5263, 2000; Miyata et al. Neuron 31:727–741, 2001; Noctor et al. Nature 409:714–720, 2001; Skogh et al. Mol Cell Neurosci 17:811–820, 2001). We propose that RG not only generate and guide newborn neurons, but could also instruct their own neuronal progeny to adopt appropriate region‐specific phenotypes. GLIA 43:47–51, 2003. © 2003 Wiley‐Liss, Inc.