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Calcium signaling in microglial cells
Author(s) -
Möller Thomas
Publication year - 2002
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.10152
Subject(s) - microglia , biology , signal transduction , neuroscience , receptor , calcium signaling , chemokine , microbiology and biotechnology , inflammation , immunology , biochemistry
Receptor‐mediated Ca 2+ signals are a common signal transduction mechanism in all living cells, including microglia. Recent years have brought major advances in our understanding of microglial Ca 2+ signaling. More than 20 receptor/ligand interactions leading to Ca 2+ signals in microglia have been described so far, and it seems that this is just the beginning. The literature has grown rapidly during the past few years, especially in regard to chemokine and ATP/UTP receptor signaling. This article presents a brief overview of the basics of Ca 2+ signaling, reviews the current literature on microglial Ca 2+ signaling, and discusses the current challenges and possible future directions of this emerging field. GLIA 40:184–194, 2002. © 2002 Wiley‐Liss, Inc.