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Regulation of the kinetics of intracerebral chemokine gene expression in murine Toxoplasma encephalitis: Impact of host genetic factors
Author(s) -
Strack Andreas,
Schlüter Dirk,
Asensio Valérie C.,
Campbell Iain L.,
Deckert Martina
Publication year - 2002
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.10104
Subject(s) - chemokine , biology , immunology , microglia , encephalitis , microbiology and biotechnology , inflammation , virus
The expression and kinetics of a panel of chemokines during Toxoplasma encephalitis (TE) were analyzed in a comparative study of genetically resistant BALB/c and susceptible C57BL/6 mice. In parallel with disease activity and the number of postinfection (p.i.) leukocytes, C57BL/6 mice induced CRG‐2/IP‐10, MuMIG, RANTES, MCP‐1, MIP‐1α, and MIP‐1β earlier and reached increased levels, as compared with BALB/c mice. These differences in the kinetics of intracerebral (i.c.) chemokines may serve as a compensatory mechanism to prevent death from necrotizing TE in C57BL/6 mice; in contrast, BALB/c mice downregulated i.c. chemokines with efficient parasite control in the chronic latent phase. Furthermore, this study showed that the pattern of i.c. chemokines and the cellular sources were identical in both strains of mice, with astrocytes and microglia expressing CRG‐2/IP‐10 and MCP‐1 or RANTES and MuMIG, respectively, and leukocytes transcribing CRG‐2/IP‐10, MCP‐1, and RANTES. Thus, the present study demonstrates that host genetic factors exert a strong impact on i.c. chemokines in experimental murine TE. GLIA 40:372–377, 2002. © 2002 Wiley‐Liss, Inc.