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Efficient unified rare variant association test by modeling the population genetic distribution in case‐control studies
Author(s) -
Li Huilin,
Chen Jinbo
Publication year - 2016
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.21995
Subject(s) - robustness (evolution) , computer science , association test , population stratification , statistic , sample size determination , genetic association , kernel (algebra) , data mining , statistics , computational biology , biology , genetics , mathematics , genotype , single nucleotide polymorphism , combinatorics , gene
Recent advancements in next‐generation DNA sequencing technologies have made it plausible to study the association of rare variants with complex diseases. Due to the low frequency, rare variants need to be aggregated in association tests to achieve adequate power with reasonable sample sizes. Hierarchical modeling/kernel machine methods have gained popularity among many available methods for testing a set of rare variants collectively. Here, we propose a new score statistic based on a hierarchical model by additionally modeling the distribution of rare variants under the case‐control study design. Results from extensive simulation studies show that the proposed method strikes a balance between robustness and power and outperforms several popular rare‐variant association tests. We demonstrate the performance of our method using the Dallas Heart Study.