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Genetic Simulation Tools for Post‐Genome Wide Association Studies of Complex Diseases
Author(s) -
Chen HuannSheng,
Hutter Carolyn M.,
Mechanic Leah E.,
Amos Christopher I.,
Bafna Vineet,
Hauser Elizabeth R.,
Hernandez Ryan D.,
Li Chun,
Liberles David A.,
McAllister Kimberly,
Moore Jason H.,
Paltoo Di.,
Papanicolaou George J.,
Peng Bo,
Ritchie Marylyn D.,
Rosenfeld Gabriel,
Witte John S.,
Gillanders Elizabeth M.,
Feuer Eric J.
Publication year - 2015
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.21870
Subject(s) - data science , computer science , resource (disambiguation) , field (mathematics) , genome wide association study , biology , genetics , single nucleotide polymorphism , computer network , mathematics , genotype , pure mathematics , gene
Genetic simulation programs are used to model data under specified assumptions to facilitate the understanding and study of complex genetic systems. Standardized data sets generated using genetic simulation are essential for the development and application of novel analytical tools in genetic epidemiology studies. With continuing advances in high‐throughput genomic technologies and generation and analysis of larger, more complex data sets, there is a need for updating current approaches in genetic simulation modeling. To provide a forum to address current and emerging challenges in this area, the National Cancer Institute (NCI) sponsored a workshop, entitled “Genetic Simulation Tools for Post‐Genome Wide Association Studies of Complex Diseases” at the National Institutes of Health (NIH) in Bethesda, Maryland on March 11–12, 2014. The goals of the workshop were to (1) identify opportunities, challenges, and resource needs for the development and application of genetic simulation models; (2) improve the integration of tools for modeling and analysis of simulated data; and (3) foster collaborations to facilitate development and applications of genetic simulation. During the course of the meeting, the group identified challenges and opportunities for the science of simulation, software and methods development, and collaboration. This paper summarizes key discussions at the meeting, and highlights important challenges and opportunities to advance the field of genetic simulation.