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Next generation analytic tools for large scale genetic epidemiology studies of complex diseases
Author(s) -
Mechanic Leah E.,
Chen HuannSheng,
Amos Christopher I.,
Chatterjee Nilanjan,
Cox Nancy J.,
Divi Rao L.,
Fan Ruzong,
Harris Emily L.,
Jacobs Kevin,
Kraft Peter,
Leal Suzanne M.,
McAllister Kimberly,
Moore Jason H.,
Paltoo Di.,
Province Michael A.,
Ramos Erin M.,
Ritchie Marylyn D.,
Roeder Kathryn,
Schaid Daniel J.,
Stephens Matthew,
Thomas Duncan C.,
Weinberg Clarice R.,
Witte John S.,
Zhang Shunpu,
Zöllner Sebastian,
Feuer Eric J.,
Gillanders Elizabeth M.
Publication year - 2012
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.20652
Subject(s) - genome wide association study , genetic epidemiology , complex disease , genetic association , data science , scale (ratio) , cluster analysis , session (web analytics) , disease , epidemiology , computational biology , computer science , biology , genetics , medicine , geography , gene , single nucleotide polymorphism , artificial intelligence , genotype , pathology , cartography , world wide web
Over the past several years, genome‐wide association studies (GWAS) have succeeded in identifying hundreds of genetic markers associated with common diseases. However, most of these markers confer relatively small increments of risk and explain only a small proportion of familial clustering. To identify obstacles to future progress in genetic epidemiology research and provide recommendations to NIH for overcoming these barriers, the National Cancer Institute sponsored a workshop entitled “Next Generation Analytic Tools for Large‐Scale Genetic Epidemiology Studies of Complex Diseases” on September 15–16, 2010. The goal of the workshop was to facilitate discussions on (1) statistical strategies and methods to efficiently identify genetic and environmental factors contributing to the risk of complex disease; and (2) how to develop, apply, and evaluate these strategies for the design, analysis, and interpretation of large‐scale complex disease association studies in order to guide NIH in setting the future agenda in this area of research. The workshop was organized as a series of short presentations covering scientific (gene‐gene and gene‐environment interaction, complex phenotypes, and rare variants and next generation sequencing) and methodological (simulation modeling and computational resources and data management) topic areas. Specific needs to advance the field were identified during each session and are summarized. Genet. Epidemiol . 36 : 22–35, 2012. © 2011 Wiley Periodicals, Inc.