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Distribution of model‐based multipoint heterogeneity lod scores
Author(s) -
Xing Chao,
Morris Nathan,
Xing Guan
Publication year - 2010
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.20535
Subject(s) - distribution (mathematics) , statistics , mathematics , mathematical analysis
The distribution of two‐point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional χ 2 approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating th e distribution of the multipoint HLOD despite its wide application. Here we want to point out that, compared with the two‐point HLOD, the multipoint HLOD essentially tests for homogeneity given linkage and follows a relatively simple limiting distribution , which can be obtained by established statistical theory. We further examine the theoretical result by simulation studies. Genet. Epidemiol . 34: 912‐916, 2010.© 2010 Wiley‐Liss, Inc.