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An evaluation of statistical approaches to rare variant analysis in genetic association studies
Author(s) -
Morris Andrew P.,
Zeggini Eleftheria
Publication year - 2010
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.20450
Subject(s) - genome wide association study , biology , genetic association , computational biology , quantitative trait locus , identification (biology) , trait , genetics , minor allele frequency , evolutionary biology , allele , allele frequency , genotype , single nucleotide polymorphism , computer science , gene , botany , programming language
Abstract Genome‐wide association (GWA) studies have proved to be extremely successful in identifying novel common polymorphisms contributing effects to the genetic component underlying complex traits. Nevertheless, one source of, as yet, undiscovered genetic determinants of complex traits are those mediated through the effects of rare variants. With the increasing availability of large‐scale re‐sequencing data for rare variant discovery, we have developed a novel statistical method for the detection of complex trait associations with these loci, based on searching for accumulations of minor alleles within the same functional unit. We have undertaken simulations to evaluate strategies for the identification of rare variant associations in population‐based genetic studies when data are available from re‐sequencing discovery efforts or from commercially available GWA chips. Our results demonstrate that methods based on accumulations of rare variants discovered through re‐sequencing offer substantially greater power than conventional analysis of GWA data, and thus provide an exciting opportunity for future discovery of genetic determinants of complex traits. Genet. Epidemiol . 34: 188–193, 2010. © 2009 Wiley‐Liss, Inc.