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On transferability of genome‐wide tagSNPs
Author(s) -
Gu C. Charles,
Yu K.,
Ketkar S.,
Templeton Alan R.,
Rao D.C.
Publication year - 2008
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.20269
Subject(s) - international hapmap project , transferability , genome , population , 1000 genomes project , computational biology , human genome , single nucleotide polymorphism , biology , computer science , genetics , genotype , logit , machine learning , demography , gene , sociology
The question of tagging single nucleotide polymorphism (tagSNP) transferability is an important one because many ongoing and upcoming Genome‐Wide Association studies rely critically upon the validity, and practical feasibility of using a universal core set of tagSNPs. A series of recent studies analyzed performance of tagSNPs selected based on the HapMap. While these studies showed largely satisfactory transferability of the tagSNPs, they also reported that the level of transferability varies, substantively sometimes, especially when tagSNPs selected in one population were used in another distant population. We present a review of the literature about where and why tagSNP transferability may become a problem and suggest research directions that may help the resolution. Genet. Epidemiol . 2008. © 2007 Wiley‐Liss, Inc.