Premium
Tag SNPs chosen from HapMap perform well in several population isolates
Author(s) -
Service Susan,
Sabatti Chiara,
Freimer Nelson
Publication year - 2007
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.20201
Subject(s) - international hapmap project , linkage disequilibrium , single nucleotide polymorphism , biology , genetics , population , snp , transferability , genetic association , tag snp , linkage (software) , allele frequency , allele , evolutionary biology , computational biology , statistics , genotype , gene , demography , logit , mathematics , sociology
Population isolates may be particularly useful for association studies of complex traits. This utility, however, largely depends on the transferability of tag SNPs chosen from reference samples, such as HapMap, to samples from such populations. Factors that characterize population isolates, such as widespread genetic drift, could impede such transferability. In this report, we show that tag SNPs chosen from HapMap perform well in several population isolates; this is true even for populations that differ substantially from the HapMap sample either in levels of linkage disequilibrium or in SNP allele frequency distributions. Genet. Epidemiol . 2007. © 2007 Wiley‐Liss, Inc.