Premium
Score test for detecting linkage to complex traits in selected samples
Author(s) -
Lebrec J.,
Putter H.,
Houwelingen J.C. van
Publication year - 2004
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.20012
Subject(s) - pedigree chart , trait , quantitative trait locus , biology , linkage (software) , genetics , population , locus (genetics) , statistics , genetic linkage , mathematics , demography , gene , computer science , sociology , programming language
We present a unified approach to selection and linkage analysis of selected samples, for both quantitative and dichotomous complex traits. It is based on the score test for the variance attributable to the trait locus and applies to general pedigrees. The method is equivalent to regressing excess IBD sharing on a function of the traits. It is shown that when population parameters for the trait are known, such inversion does not entail any loss of information. For dichotomous traits, pairs of pedigree members of different phenotypic nature (e.g., affected sib pairs and discordant sib pairs) can easily be combined as well as populations with different trait prevalences. © 2004 Wiley‐Liss, Inc.