Premium
Assessing Linkage of Immunoglobulin E Using a Meta‐Analysis Approach
Author(s) -
Etzel Carol J.,
Costello Tracy J.
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s97
Subject(s) - linkage (software) , genetic linkage , quantitative trait locus , genetics , lod score , chromosome , biology , univariate analysis , univariate , mathematics , gene mapping , statistics , gene , multivariate analysis , multivariate statistics
We report results using a new meta‐analysis procedure to assess linkage of immunoglobulin E (IgE), an asthma related quantitative trait, using the nine data sets provided by the Genetic Analysis Workshop 12. This meta‐analysis procedure combines univariate Haseman‐Elston statistics across studies gaining strength by collating possibly distinct marker maps. We performed univariate Haseman‐Elston over all data sets and identified linkage (p < 0.05) to some marker in at least one study on virtually every chromosome. Using the proposed meta‐analysis procedure, we detected suggestive linkage (p‐value < 7.4 x 10 ‐4 , [Lander and Kruglyak, Nat Genet 11:214–47, 1995]) for two regions on chromosome 4 (around 50 and 150 cM) and one region on chromosome 11 (around 125 cM). We also identified areas which were evocative (p‐value < 0.02) for linkage: chr 5 ~40 cM, chr 7 ~98 cM, chr 9 ~65 cM, chr 13 ~110 cM, chr 16 ~10 cM and ~105 cM, chr 17 ~70 cM, and chr 20 ~25 cM. © 2001 Wiley‐Liss, Inc.