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Distribution of lod Scores in Oligogenic Linkage Analysis
Author(s) -
Williams Jeff T.,
North Karl E.,
Martin Lisa J.,
Comuzzie Anthony G.,
Göring Harald H.H.,
Blangero John
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s805
Subject(s) - quantitative trait locus , statistics , linkage (software) , statistic , mathematics , trait , genetic linkage , population , genetics , biology , computer science , medicine , gene , environmental health , programming language
In variance component oligogenic linkage analysis it can happen that the residual additive genetic variance bounds to zero when estimating the effect of the i th quantitative trait locus. Using quantitative trait Q1 from the Genetic Analysis Workshop 12 simulated general population data, we compare the observed lod scores from oli‐gogenic linkage analysis with the empirical lod score distribution under a null model of no linkage. We find that zero residual additive genetic variance in the null model alters the usual distribution of the likelihood‐ratio statistic. © 2001 Wiley‐Liss, Inc.