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The Utility of Bayesian Model Averaging for Detecting Known Oligogenic Effects
Author(s) -
Martin Lisa J.,
Comuzzie Anthony G.,
North Kari E.,
Williams Jeff T.,
Blangero John
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s789
Subject(s) - bayesian probability , quantitative trait locus , trait , biology , computer science , statistics , mathematics , genetics , gene , programming language
In this paper we examine the utility of the Bayesian model averaging approach proposed by Blangero et al. [Genet Epidemiol 17(Suppl. 1):S67–72, 1999] for the detection of known oligogenic effects on quantitative trait 1 (Q1) in the simulated Genetic Analysis Workshop 12 data. The results were consistent with the underlying genetic model: two major QTLs were identified on chromosomes 19 and 2, with heritabilities of 17% and 20%, respectively, located near the position of major genes 1 and 2. © 2001 Wiley‐Liss, Inc.