Premium
The Power of Transmission Disequilibrium Tests for Quantitative Traits
Author(s) -
Li Jinming,
Wang Dai,
Dong Jianping,
Jiang Renfang,
Zhang Kui,
Zhang Shuanglin,
Zhao Hongyu,
Sun Fengzhu
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s632
Subject(s) - linkage disequilibrium , disequilibrium , linkage (software) , statistic , transmission disequilibrium test , haplotype , similarity (geometry) , genetic association , biology , test statistic , statistics , computational biology , statistical hypothesis testing , genetics , computer science , mathematics , artificial intelligence , genotype , single nucleotide polymorphism , medicine , gene , ophthalmology , image (mathematics)
We develop a score statistic to test for linkage in the presence of linkage disequilibrium for quantitative traits. We then extend this method to analyze multiple tightly linked markers. One potential limitation with the use of many genetic markers is the large number of degrees of freedom involved that may reduce the overall power to detect linkage. To overcome this limitation, we propose to group haplotypes on the basis of haplotype similarity before performing transmission disequilibrium tests. Finally, we apply these methods to the Genetic Analysis Workshop 12 simulated data and compare their power. © 2001 Wiley‐Liss, Inc.