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Genome Scan of Complex Traits by Haplotype Sharing Correlation
Author(s) -
Qian Dajun,
Thomas Duncan C.
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s582
Subject(s) - haplotype , biology , genetics , genome scan , genome , microsatellite , correlation , similarity (geometry) , computational biology , gene , phenotype , evolutionary biology , genotype , allele , computer science , artificial intelligence , mathematics , geometry , image (mathematics)
We introduce a haplotype‐sharing correlation in founder haplotypes for use in genome scanning. The method evaluates the correlation between phenotype similarity and haplotype similarity at each candidate location. When applied to Genetic Analysis Workshop 12 simulated data for disease status, age at onset, and quantitative traits Q1–Q5, we found highly significant signals near four simulated disease loci in genome scans using microsatellite marker data and highly significant gene effects in three casual genes using sequence data. © 2001 Wiley‐Liss, Inc.