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Exploring Haplotype Sharing Methods in General and Isolated Populations to Detect Gene(s) of a Complex Genetic Trait
Author(s) -
Beckmann Lars,
Fischer Christine,
Deck Klaus-Georg,
Nolte Ilja M.,
te Meerman Gerard,
Chang-Claude Jenny
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s554
Subject(s) - haplotype , genetics , biology , linkage disequilibrium , population , quantitative trait locus , genetic linkage , chromosome , linkage (software) , gene , allele , demography , sociology
We applied a new haplotype sharing method to the simulated Genetic Analysis Workshop 12 data for both isolated and general populations without knowledge of the disease model, using affection status as phenotype and three different sample sizes. The highest peak for the mean sharing of the haplotypes was found in the isolated population for the markers D06G034 and D06G035, which flank the candidate genes located on chromosome 6, with ‐log 10 (p) values of 2.9 and 7.0 in the moderate and large study samples, respectively. The whole genome screen detected three further loci with ‐log 10 (p) values of 3.0, which turned out to be false positives. None of the true gene loci were detected in the general population even in the largest sample. The test of linkage disequilibrium based on excess haplotype sharing over the linkage equilibrium expectation revealed z‐values one order of magnitude higher in the isolated than in the general population. This approach appears to be promising for mapping genes of complex diseases depending on population characteristics. © 2001 Wiley, Liss, Inc.