Premium
Exploiting Linkage Disequilibrium in Population Isolates
Author(s) -
Culverhouse Robert,
Lin Jennifer,
Liu Kuang-Yu,
Suarez Brian K.
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s429
Subject(s) - linkage disequilibrium , genetics , biology , haplotype , linkage (software) , disequilibrium , sample size determination , allele , population , chromosome , allele frequency , evolutionary biology , population genetics , statistics , mathematics , demography , gene , medicine , sociology , ophthalmology
A comparison of haplotype frequencies between unrelated cases and controls from population isolates identifies a strong signal for the presence/absence of the discrete phenotype in an interval on chromosome 6 bounded by markers 34 and 35. We define a dissimilarity index, D, which is sensitive to differences in allele distributions and differences in the patterns of linkage disequilibrium between cases and controls. We describe two statistical methods to utilize D: a method appropriate for a single moderately sized sample and a sequential approach appropriate for multiple small independent samples. © 2001 Wiley‐Liss, Inc.