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Comparison of the QTDT Analysis for IgE in the CSGA Data Set
Author(s) -
Page Grier P.,
Wilcox Marsha A.,
Occhiuto Jane,
Adak Sudeshna,
Neuberg Donna,
Bajorunaite Ruta,
George Varghese
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s312
Subject(s) - covariate , linkage disequilibrium , linkage (software) , statistics , transmission disequilibrium test , data set , asthma , biology , mathematics , medicine , genetics , genotype , immunology , haplotype , gene
Over the past few years at least 13 transmission/disequilibrium test (TDT)‐based tests have been developed for quantitative (Q) traits for the assessment of association or linkage in the presence of the other. A total of six of these QTDT methods were used to analyze log 10 IgE in the Collaborative Study on the Genetics of Asthma data set. Only moderate agreement was found between the tests. The results of the QTDT analyses were only slightly affected by the use of gender and age as covariates. Results from analysis of IgE and log 10 IgE were inconsistent. Our conclusion is that there is only modest agreement among the QTDT methods examined, covariates should be used even if they have a small effect, and that data should be normalized before analysis. © 2001 Wiley‐Liss, Inc.