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Comparison of Sib Pair‐Based Approaches for Identifying Quantitative Trait Loci Underlying Asthma in the Busselton Families
Author(s) -
Shugart Yin Y.,
Specchia Claudia,
Li Hui-Hua,
Doan Betty Q.,
Mathias Rasika A.,
Devoto Marcella
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s198
Subject(s) - quantitative trait locus , microsatellite , linkage (software) , lod score , biology , inclusive composite interval mapping , genetics , genetic linkage , locus (genetics) , trait , chromosome , gene mapping , computer science , allele , gene , programming language
The goal of this study is to determine the linkage relationship between IgE levels and the 269 microsatellite markers using the Genetic Analysis Workshop 12 Busselton data set. Analyses were carried out using both traditional and new Haseman‐Elston methods, the maximum likelihood quantitative trait locus estimation (MLE QTL) method and the nonparametric (NP QTL) method. Our analyses confirmed some of the signals reported by Daniels et al. [Nature 383:247–50, 1996]. We also observed that several significant signals reported in the original report became insignificant (D6S76 and D11S96) and several new signals showed up after the data were reanalyzed using the new Haseman‐Elston method, the MLE QTL method, and the NP QTL method. Based on the original and the current analyses, we recommend that follow‐up studies of three regions including D7S2250, FCER1B, D11S901, and six markers on chromosome 16 be given higher priority. © 2001 Wiley‐Liss, Inc.