Premium
Detection of Parent‐of‐Origin Effects for Atopy by Model‐Free and Model‐Based Linkage Analyses
Author(s) -
Demenais Florence,
Chaudru Valérie,
Martinez Maria
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s186
Subject(s) - atopy , allele , genetics , linkage (software) , biology , imprinting (psychology) , genetic linkage , genomic imprinting , nuclear family , gene , asthma , immunology , gene expression , dna methylation , sociology , anthropology
Parent‐of‐origin effects for atopy were investigated by a model‐free affected sib‐pair (ASP) method and two model‐based approaches in the Busselton nuclear families. Among the regions showing potential linkages to atopy by the ASP method, a significant excess of paternal allele sharing as compared with maternal allele sharing was observed for a cluster of three markers on chromosome 13. The two model‐based methods, which specify either sex‐specific recombination rates or different penetrances for heterozygotes according to the parental origin of disease allele (imprinting), led to the same results, both suggesting a paternal effect. Thus, these two ways of modelling parent‐of‐origin effects appear equivalent in nuclear family data. Further simulations arc needed to investigate whether the mechanisms underlying parent‐of‐origin effects can be distinguished in larger pedigree structures. © 2001 Wiley‐Liss, Inc.