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Genetic Analysis of Quantitative Traits in Highly Ascertained Samples: Total Serum IgE in Families with Asthma
Author(s) -
Bethony Jeffrey,
Williams Jeff T.,
Almasy Laura,
Corrêa-Oliveira Rodrigo,
Blangero John C.,
Williams-Blangero Sarah
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s174
Subject(s) - quantitative trait locus , proband , asthma , linkage (software) , trait , genetic linkage , immunoglobulin e , population , biology , genetics , medicine , immunology , antibody , gene , mutation , environmental health , computer science , programming language
The objective of this study was to compare the effect of an approximate ascertainment correction using proband phenotypes with heuristic corrections based on sample trait means and on published “standard” population values. Data were from the Collaborative Study on the Genetics of Asthma, which comprises 225 families ascertained through sib pairs affected with asthma. In variance component linkage analysis of IgE no lod scores greater than 3.0 were observed, either with or without several attempted corrections for ascertainment. The ascertained nature of the sample may have compromised the power to detect linkage to a quantitative trait (IgE) associated with the focal phenotype (asthma). © 2001 Wiley‐Liss, Inc.