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A Joint Analysis of Asthma Affection Status and IgE Levels in Multiple Data Sets Collected for Asthma
Author(s) -
Markianos Kyriacos,
Carlson Scott,
Gibbs Mark,
Kruglyak Leonid
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s148
Subject(s) - linkage (software) , asthma , affection , immunoglobulin e , genome scan , genetic linkage , chromosome , genome , medicine , phenotype , genetics , immunology , biology , gene , psychology , microsatellite , antibody , social psychology , allele
We present a joint linkage analysis of eight data sets collected for asthma. Three of the data sets are full genome scans, while the remaining five concentrate on a 40‐cM region on chromosome 5. We perform the analysis using one qualitative and one quantitative phenotype: asthma status and IgE level. Considering all data sets simultaneously, we do not find evidence for linkage to asthma affection status beyond the level expected to occur by chance twice per genome scan. In contrast, we observe significant linkage to IgE level on chromosome 6. © 2001 Wiley‐Liss, Inc.