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Weighting Schemes in Pooled Linkage Analysis
Author(s) -
Loesgen Sabine,
Dempfle Astrid,
Golla Astrid,
Bickeböller Heike
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s142
Subject(s) - weighting , statistic , linkage (software) , nonparametric statistics , statistics , genetic linkage , summary statistics , computer science , computational biology , biology , genetics , mathematics , gene , medicine , radiology
To identify susceptibility gene regions for complex diseases a combined linkage analysis of several genome scans might give additional insights to individual studies. In this article we consider different weighting schemes to combine the score statistics of individual studies to an overall statistic within multipoint nonparametric linkage analysis by GENEHUNTER/ALLEGRO. With the Genetic Analysis Workshop (GAW) 12 asthma data sets the weights are dominated by the large differences in the relevant sample sizes. © 2001 Wiley‐Liss, Inc.