Premium
Meta‐analysis of linkage studies
Author(s) -
Badner Judith A.,
Goldin Lynn R.
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370170778
Subject(s) - linkage (software) , statistics , genome , point estimation , lod score , econometrics , mathematics , biology , genetics , gene mapping , gene , chromosome
Lander and Kruglyak [1995] gave guidelines for interpreting linkage results based on estimating how often a particular threshold for significance would be exceeded by chance in a single genome scan. What is unknown is how often two or more genome scans would exceed a particular threshold within the same region. We develop theoretical estimates of these values and compare these with the empirical estimates derived from the GAW11 data. For single‐point analysis, the theoretical estimates predict the empirical estimates. For multipoint analysis, the theoretical values overestimate what is observed. For both single point and multipoint, modest p‐values within a single genome scan may give highly significant results when replicated in the same region in other scans.