Premium
Genome search for alcohol dependence using the weighted pairwise correlation linkage method: Interesting findings on chromosome 4
Author(s) -
ZinnJustin Anne,
Abel Laurent
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370170771
Subject(s) - linkage (software) , genetics , pairwise comparison , identity by descent , correlation , autosome , genetic linkage , biology , chromosome , gene , mathematics , computational biology , statistics , haplotype , allele , geometry
The nonparametric (model‐free) method of linkage analysis Weighted Pairwise Correlation (WPC) has been proposed by Commenges [1994], and extended to incorporate identity‐by‐descent (IBD) information [Zinn‐Justin and Abel, 1999]. We performed an autosome‐wide scan in the Collaborative Study on the Genetics of Alcoholism data using the WPC‐IBD method, considering two phenotypes related to alcohol dependence defined as residuals of binary traits adjusted for age and sex. Three chromosome 4 markers located in a region of 50 cM spanning from GABRB1 to D4S1651 provided Monte Carlo (MC) p‐values lower than 0.005, confirming the possible influence of β1 GABA receptor and ADH genes in alcoholism. Furthermore, marker D15S642, not far from the ALDH6 gene, provided an MC p‐value of 0.0005 in ethnic groups “White, Hispanic” and “White, non‐Hispanic.”