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Asymptotic power of likelihood‐ratio tests for detecting quantitative trait loci using the COGA data
Author(s) -
Williams Jeff T.,
Blangero John
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370170767
Subject(s) - quantitative trait locus , heritability , biology , genetics , linkage (software) , trait , locus (genetics) , genetic linkage , statistical power , likelihood ratio test , statistics , mathematics , gene , computer science , programming language
Abstract We investigated the asymptotic power of the likelihood‐ratio test for detecting linkage to a quantitative trait locus (QTL) using the data set from the Collaborative Study on the Genetics of Alcoholism (COGA). Assuming a total trait heritability of 50% as determined for the COGA Cz P300 phenotype, we determined the minimum QTL heritability required at each point in the genome to achieve 80% power to detect linkage with a lod of 3.0. We find that there are regions of the genome where it is not possible to detect a QTL of any effect with 80% power, and that the overall minimum detectable QTL heritability for the COGA data is 0.35–0.40.