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Association and linkage analysis of ICD‐10 diagnosis for alcoholism
Author(s) -
Tiwari Hemant K.,
Zhu Xiaofeng,
Elston Robert C.,
Shu Youyi,
George Varghese
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370170758
Subject(s) - linkage (software) , quantitative trait locus , genetics , genetic linkage , allele , biology , trait , association mapping , genetic association , single nucleotide polymorphism , genotype , gene , computer science , programming language
We analyzed the GAW11 data on alcoholism provided by the Collaborative Study on the Genetics of Alcoholism (COGA) using an extension of a new test of linkage and association for quantitative traits developed by George et al. [1999]. This method determines linkage between marker loci and quantitative traits, when allelic association is present between the trait and marker loci, by regressing the disease trait on the parental transmission of the allele of interest. We found no strong evidence of linkage to any markers. However, we found several markers suggestive of possible linkage that may deserve further investigation.