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Linkage analysis with adequate modeling of a parent‐of‐origin effect
Author(s) -
Strauch Konstantin,
Fimmers Rolf,
Windemuth Christine,
Hahn Andreas,
Wienker Thomas F.,
Baur Max P.
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370170756
Subject(s) - genetic linkage , imprinting (psychology) , genetics , locus (genetics) , allele , genomic imprinting , linkage (software) , biology , parametric statistics , gene , statistics , mathematics , gene expression , dna methylation
We present an extension to parametric linkage analysis that allows modeling diseases with a parent‐of‐origin effect (i.e., imprinting). Different penetrances are assumed for individuals being heterozygous at the disease locus, depending on their having inherited the disease allele from the father or mother. Motivated by the finding of a maternally expressed locus influencing alcohol consumption in mice (A1cp2), the analysis method has been included into the program GENEHUNTER for application to Problem 1, Collaborative Study on the Genetics of Alcoholism of Genetic Analysis Workshop 11. By this extension, a powerful tool is provided for adequately modeling an inherited disease in linkage analysis that supposedly has imprinting effects. The program has been used to analyze the data set on alcohol dependence in humans and can be applied to other genetically determined traits as well.