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Quantitative trait transmission disequilibrium test: Allowance for missing parents
Author(s) -
Schaid Daniel J.,
Rowland Charles M.
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370170752
Subject(s) - disequilibrium , allowance (engineering) , transmission disequilibrium test , trait , statistics , test (biology) , biology , econometrics , genetics , mathematics , computer science , medicine , economics , ecology , single nucleotide polymorphism , gene , genotype , ophthalmology , programming language , operations management
The association of a quantitative trait with transmission disequilibrium of parental marker alleles can be a powerful method to discover the genetic basis of the trait. However, current methods require marker genotypes on all parents. We present a new method that allows the assessment of the association of a quantitative trait with transmission disequilibrium of marker alleles when parental marker genotypes are missing, but marker genotypes for sibships are available. Because our approach is based on regression methods, additional covariates, including multiple marker loci, can be included in our proposed method of analysis. Application of this methodology to the COGA data to assess the association of quantitative traits (ERPs) with marker loci on chromosome 7 failed to identify statistically significant transmission disequilibrium.