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Novel tests for marker‐disease association using the collaborative study on the genetics of alcoholism data
Author(s) -
Nielsen Dahlia,
Zaykin Dmitri
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370170745
Subject(s) - transmission disequilibrium test , linkage disequilibrium , genetic association , locus (genetics) , genetics , bayesian probability , association (psychology) , association test , disease , biology , allele , psychology , medicine , haplotype , statistics , genotype , single nucleotide polymorphism , mathematics , gene , psychotherapist
We applied several novel tests for association and linkage in the presence of association to the Genetic Analysis Workshop 11 Problem 1 data set. Our analyses included a Hardy‐Weinberg test for association between a marker and a disease susceptibility locus, a Bayesian transmission/disequilibrium test, and a Bayesian case‐control test. Positive results for each of these methods require the presence of population association between the marker and a disease susceptibility locus.