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Alcoholism as a complex trait: Comparison of genetic models and role of epidemiological risk factors
Author(s) -
Macciardi Fabio,
Morenghi Emanuela,
Morabito Alberto
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370170742
Subject(s) - trait , epidemiology , genetic epidemiology , quantitative trait locus , biology , genetics , medicine , gene , computer science , programming language
A genetic component for alcoholism appears likely, but the genes involved have yet to be identified. The mode of inheritance is probably more complex than for traditional mendelian disorders. In particular, there are marked differences in alcoholism by gender, parent‐of‐origin effects, ethnicity, and other epidemiological factors. We investigated the evidence for the presence of susceptibility genes for alcohol dependence in the Collaborative Study on the Genetics of Alcoholism data set.