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A low density genome‐wide search for loci involved in alcohol dependence using the transmission/disequilibrium test, sib‐tdt, and two combined tests
Author(s) -
Camp Nicola J.,
Bansal Aruna
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370170715
Subject(s) - linkage disequilibrium , transmission disequilibrium test , linkage (software) , genetics , biology , genome , disequilibrium , genetic association , computational biology , genetic linkage , haplotype , gene , allele , genotype , medicine , single nucleotide polymorphism , ophthalmology
The transmission/disequilibrium test (TDT), sib‐TDT and two combined tests have been implemented in an attempt to identify loci across the genome that may be involved in alcohol dependence. Since these tests are based on the existence of association between marker and disease loci, the low‐density map used (13 cM) will have missed any disease loci situated between markers. Nevertheless, genome‐wide suggestive linkage results were found at three markers ‐ D6S474, D8S1715, and D12S372 ‐ two of which also gave nominally significant evidence by two‐point linkage analysis. These are regions that deserve further investigation with respect to their involvement in alcohol dependence, and in order to evaluate the relative efficacy of the different methods used.