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Systematic search for susceptibility genes in different populations
Author(s) -
Schmidt Silke,
Scholz Michael,
Loesgen Sabine,
Bickeböller Heike
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.13701707116
Subject(s) - genetics , biology , linkage (software) , chromosome , genetic linkage , gene , replicate , population , genome , genome scan , genetic marker , genetic association , quantitative trait locus , evolutionary biology , single nucleotide polymorphism , microsatellite , genotype , allele , medicine , statistics , mathematics , environmental health
We analyzed the first replicate of each of the four simulated population samples from three distinct populations by linkage and association genome scans and could identify three regions with susceptibility loci for the disease: on chromosome 1, marker D1G024, with strong evidence for gene×environment interaction; on chromosome 3, around marker D3G045; and on chromosome 5, markers D5G035–D5G042. Our results were obtained without knowing the true disease model and are compared with this model in the discussion.