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Generalization of the extended transmission disequilibrium test to two unlinked disease loci
Author(s) -
Morris Andrew,
Whittaker John
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.13701707108
Subject(s) - linkage disequilibrium , locus (genetics) , genetics , biology , epistasis , allele , disequilibrium , transmission disequilibrium test , genetic linkage , haplotype , gene , medicine , ophthalmology
The extended transmission disequilibrium test (ETDT) of Sham and Curtis [1995] is a powerful test of the null hypothesis of no linkage between a multi‐allelic marker locus and a disease susceptibility locus of unknown location in the presence of association between alleles at the two loci. We propose a generalization of the ETDT to test simultaneously for linkage of markers to two unlinked disease loci. Analysis of the simulated data for Problem 2 would suggest improvements in power to detect linkage to pairs of disease loci over single locus tests. This is as a result of the two locus model taking account of epistasis between the disease loci.