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A comparison of some allele‐sharing based linkage analysis methods for detecting complex trait loci
Author(s) -
Liu Ying,
Mirea Lucia,
Pinnaduwage Dushanthi,
Fallah Shafagh,
Tritchler David
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.13701707104
Subject(s) - linkage (software) , quantitative trait locus , regression analysis , genetic linkage , allele , analysis of variance , genetics , regression , trait , statistics , biology , mathematics , computer science , gene , programming language
Using randomly selected sib pairs from a subset of the GAW11 simulated data in Problem 2, we compared the results of some linkage analysis methods based on allele sharing. One method was the Haseman‐Elston test for a binary disease outcome (unaffected vs. mild or severe). The other methods, which analyzed the trinary ordered outcome unaffected/mild/severe were the Haseman‐Elston test, an extended Haseman‐Elston incorporating sib‐pair sums, variance components analysis, and regression analysis. Our analysis was done without knowledge of the generating model.