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Nonparametric linkage and family‐based association studies of a simulated complex disorder
Author(s) -
Koller Daniel L.,
Balding Joanna,
Foroud Tatiana
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.13701707102
Subject(s) - linkage (software) , genetics , genetic linkage , biology , sibling , trait , genetic association , quantitative trait locus , logistic regression , nonparametric statistics , regression , gene , genotype , statistics , psychology , mathematics , computer science , single nucleotide polymorphism , developmental psychology , programming language
Affected sibling pairs are widely used to identify chromosomal regions harboring genetic loci underlying common disease. We explore the utility of nonparametric sibling pair and family‐based association methods to search for disease susceptibility loci in simulated pedigree data for a qualitative disease trait. Logistic regression was used to model gene×gene and gene×environment interactions when significant linkage and association were detected. Using these methods, we were able to detect three of the four susceptibility loci underlying the disease trait with multipoint lod scores of 1.0 or greater.