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Computing conditional recombination probabilities given marker information
Author(s) -
Miller Michael B.
Publication year - 1995
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370120659
Subject(s) - interference (communication) , chiasma , conditional probability , allele , offspring , recombination , computation , genetics , mathematics , computer science , biology , statistics , algorithm , gene , pregnancy , computer network , channel (broadcasting) , chromosome
When a parent is homozygous, it is not possible to determine directly whether offspring share an allele identical by descent (IBD) from that parent. However, an IBD probability can be computed using information from linked loci where the parent is heterozygous. To solve this problem for the phase‐known case, probability equations and a computer program were developed for efficient computation of conditional probabilities under a Sturt model of chiasma interference. Data are analyzed and contrasted with and without taking interference into account. The effect of failing to account for interference is very small, but the computational cost is also small. © 1995 Wiley‐Liss, Inc.