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A Chromosome‐based method to infer IBD scores for missing and ambiguous markers
Author(s) -
Gu Chi,
Suarez Brian K.,
Reich Theodore,
Todorov Alexandre A.
Publication year - 1995
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370120657
Subject(s) - lod score , identity by descent , linkage (software) , missing data , chromosome , genetic linkage , genetics , joint probability distribution , data set , mathematics , biology , statistics , computational biology , computer science , gene mapping , gene , haplotype , genotype
We propose a probability model to impute missing identical‐by‐descent (IBD) vectors for linkage analysis, when adjacent marker loci are typed and interference is estimable. A chromosome‐based IBD distribution, conditioned on available marker data, is computed using a fast algorithm to estimate the joint probability of genes IBD at several equally spaced linked loci. Weighted IBD vectors are then used in various test statistics for linkage analysis. As an example, we analyzed the 18 affected sib pairs in the GAW9 Problem 1 data set using Risch's lod‐score test. © 1995 Wiley‐Liss, Inc.