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Analysis of breast cancer pedigrees using affected sibship methods
Author(s) -
Barrett Jennifer H.,
Rigby Alan S.
Publication year - 1995
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370120653
Subject(s) - pedigree chart , breast cancer , biology , oncology , statistics , genetics , cancer , mathematics , medicine , gene
Abstract Haplotype‐sharing was examined in sets of affected siblings in the Breast Cancer Linkage Consortium pedigrees [Easton et al., 1993], using both identity‐by‐descent and identity‐by‐state methods. Linkage of the disease susceptibility locus to markers on chromosome 17 was confirmed. Substantial genetic heterogeneity was found, with more young cases being attributable to the putative gene. No differences were found between breast and ovarian cancer, and there was no evidence against a simple dominant mode of inheritance. © 1995 Wiley‐Liss, Inc.