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Two‐locus approach of segregation and linkage analysis in the study of complex traits
Author(s) -
Xu Jianfeng,
Taylor Eugene W.,
Panhuysen Carolien I. M.,
Prenger Valerie L.,
Koskela Rebecca,
Kiemeney Bart,
LaBuda Michele C.,
Maestri Nancy E.,
Meyers Deborah A.
Publication year - 1995
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370120649
Subject(s) - locus (genetics) , mendelian inheritance , genetics , genetic linkage , trait , biology , quantitative trait locus , gene , computer science , programming language
A two‐locus segregation and linkage‐analysis approach was used to characterize the genetic control of a complex trait (Q1) and to localize the genes that have detectable effects. The results suggested that a two‐locus Mendelian model fit the data significantly better than a one‐locus model. The linkage results based on the most parsimonious two‐locus model revealed linkage of Q1 to two areas (MG2 and MG3), while there was less evidence for linkage using one‐locus models. Results also suggested that the subphenotypes (Q2 and Q3) provided useful information for further analysis of Q1 using two‐locus models. © 1995 Wiley‐Liss, Inc.