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Evaluation of genetic and environmental effects using GEE and APM methods
Author(s) -
Bull S. B.,
Chapman N. H.,
Greenwood C. M. T.,
Darlington G. A.
Publication year - 1995
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370120633
Subject(s) - gee , generalized estimating equation , affection , linkage (software) , statistics , trait , set (abstract data type) , mathematics , econometrics , biology , genetics , gene , psychology , computer science , social psychology , programming language
Two analytic methods were used in the Problem 2 data set. First, generalized estimating equations (GEE) modelling was developed to adjust for familial correlation in regressions evaluating candidate genes and an environmental factor. Second, the affected‐pedigree‐member (APM) method was used to identify chromosomal regions of interest and linkage of candidate genes with disease affection status. The GEE method identified C5 (MG1) as important for the quantitative trait Q1 and the corresponding affection status DIS, but the APM method was only suggestive. The GEE method identified C2 (MG2) as important for Q2 but only marginally important for Q1 and not important for DIS. © 1995 Wiley‐Liss, Inc.