A brute force dichotomization approach to quantitative trait linkage analysis | Zendy

Bailey Julia N. | Zendy; Almasy Laura | Zendy

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A brute force dichotomization approach to quantitative trait linkage analysis

Author(s) -

Bailey Julia N.,

Almasy Laura

Publication year - 1995

Publication title -

genetic epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.301

H-Index - 98

eISSN - 1098-2272

pISSN - 0741-0395

DOI - 10.1002/gepi.1370120631

Subject(s) - trait , quantitative trait locus , linkage (software) , genetic linkage , covariate , genetics , biology , computational biology , evolutionary biology , statistics , mathematics , computer science , gene , programming language

The effect of dichotomizing a continuous phenotype in linkage analysis of a simulated oligogenic trait is explored. We conclude that dichotomization does not in itself preclude the detection of loci which account for as little as 16% of the genetic variance of the disease. The effects of inclusion of known covariates and quantitative trait linkage analysis are also discussed. © 1995 Wiley‐Liss, Inc.

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