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TDT with covariates and genomic screens with mod scores: Their behavior on simulated data
Author(s) -
Rice John P.,
Neuman Rosalind J.,
Hoshaw Stacy L.,
Daw E. Warwick,
Gu Chi
Publication year - 1995
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370120623
Subject(s) - covariate , transmission disequilibrium test , locus (genetics) , genetics , biology , linkage disequilibrium , population , allele , score test , disequilibrium , multiple comparisons problem , statistics , offspring , mathematics , likelihood ratio test , medicine , haplotype , gene , pregnancy , environmental health , ophthalmology
We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus. © 1995 Wiley‐Liss, Inc.