TDT with covariates and genomic screens with mod scores: Their behavior on simulated data | Zendy

Rice John P. | Zendy; Neuman Rosalind J. | Zendy; Hoshaw Stacy L. | Zendy; Daw E. Warwick | Zendy; Gu Chi | Zendy

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TDT with covariates and genomic screens with mod scores: Their behavior on simulated data

Author(s) -

Rice John P.,

Neuman Rosalind J.,

Hoshaw Stacy L.,

Daw E. Warwick,

Gu Chi

Publication year - 1995

Publication title -

genetic epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.301

H-Index - 98

eISSN - 1098-2272

pISSN - 0741-0395

DOI - 10.1002/gepi.1370120623

Subject(s) - covariate , transmission disequilibrium test , locus (genetics) , genetics , biology , linkage disequilibrium , population , allele , score test , disequilibrium , multiple comparisons problem , statistics , offspring , mathematics , likelihood ratio test , medicine , haplotype , gene , pregnancy , environmental health , ophthalmology

We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus. © 1995 Wiley‐Liss, Inc.

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