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Screening for linkage and association in nuclear families
Author(s) -
Knapp M.,
Durner M.,
Baur M. P.
Publication year - 1995
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370120616
Subject(s) - linkage (software) , genetic linkage , genetics , biology , genetic association , nuclear family , association mapping , lod score , association (psychology) , gene mapping , gene , genotype , psychology , single nucleotide polymorphism , chromosome , sociology , anthropology , psychotherapist
We applied linkage analysis with a sib‐pair method, which also takes into account information on unaffected siblings, and family‐based methods of association analysis to determine the disease affecting loci in Problem 1. Whereas the first two disease loci were correctly identified by association analysis, the sib‐pair linkage method failed to detect the disease loci 3 and 4. We therefore determined the data structure and sample size necessary for demonstrating linkage to these loci. ©1995 Wiley‐Liss, Inc.