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Screening a 2 cM genetic map for allelic association: A simulated oligogenic trait
Author(s) -
Duffy David L.
Publication year - 1995
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370120612
Subject(s) - transmission disequilibrium test , association mapping , disequilibrium , trait , genetic association , genetics , linkage disequilibrium , allele , biology , quantitative trait locus , computational biology , multiple comparisons problem , evolutionary biology , association (psychology) , statistics , computer science , mathematics , haplotype , single nucleotide polymorphism , medicine , gene , genotype , ophthalmology , programming language , philosophy , epistemology
In this paper, we explore the use of a variety of familial transmission tests (and case‐control analyses) to screen for allelic associations in simulated marker data of a quality (2 cM map) that will feasibly arise from genomic scans within the next 5‐10 years. We demonstrate a form of the transmission‐disequilibrium test extended to multiallele systems. The methods used were log‐linear and related models implemented largely using standard statistical packages. ©1995 Wiley‐Liss, Inc.