Screening a 2 cM genetic map for allelic association: A simulated oligogenic trait | Zendy

Duffy David L. | Zendy

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Screening a 2 cM genetic map for allelic association: A simulated oligogenic trait

Author(s) -

Duffy David L.

Publication year - 1995

Publication title -

genetic epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.301

H-Index - 98

eISSN - 1098-2272

pISSN - 0741-0395

DOI - 10.1002/gepi.1370120612

Subject(s) - transmission disequilibrium test , association mapping , disequilibrium , trait , genetic association , genetics , linkage disequilibrium , allele , biology , quantitative trait locus , computational biology , multiple comparisons problem , evolutionary biology , association (psychology) , statistics , computer science , mathematics , haplotype , single nucleotide polymorphism , medicine , gene , genotype , ophthalmology , programming language , philosophy , epistemology

In this paper, we explore the use of a variety of familial transmission tests (and case‐control analyses) to screen for allelic associations in simulated marker data of a quality (2 cM map) that will feasibly arise from genomic scans within the next 5‐10 years. We demonstrate a form of the transmission‐disequilibrium test extended to multiallele systems. The methods used were log‐linear and related models implemented largely using standard statistical packages. ©1995 Wiley‐Liss, Inc.

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