Premium
Asymptotic distributions of polylocus test statistics
Author(s) -
Goldstein Darlene R.
Publication year - 1995
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370120207
Subject(s) - statistics , mathematics , score test , hum , null distribution , null hypothesis , likelihood ratio test , econometrics , asymptotic analysis , statistical hypothesis testing , demography , sociology , test statistic , history , performance art , art history
Polylocus linkage analysis methods are modified two‐point analyses which aim to approach the information gain of multilocus analysis. Terwilliger and Ott [(1992) Am J Hum Genet 51:A202, (1993) Genet Epidemiol 10:477–482] put forth two such methods. This paper presents asymptotic approximations to the null distribution of the likelihood ratio statistics for these two methods, correcting earlier reports [Terwilliger and Ott (1993) Genet Epidemiol 10:477–482; Schaid and Elston (1994) Genet Epidemiol 11:1–17]. The performance of the approximations is then assessed for finite samples of fully informative meioses. © 1995 Wiley‐Liss, Inc.