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Familial risks for Alzheimer disease from a population‐based series
Author(s) -
Hirst C.,
Yee I. M. L.,
Sadovnick A. D.
Publication year - 1994
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370110406
Subject(s) - disease , confidence interval , lifetime risk , consistency (knowledge bases) , series (stratigraphy) , population , autopsy , alzheimer's disease , demography , medicine , biology , mathematics , paleontology , geometry , sociology
Kaplan‐Meier risks estimates are calculated and compared for two consecutive series ( N 1 = 840, N 2 = 819) of first‐degree relatives of Alzheimer disease (AD) patients diagnosed as either “probable” or “autopsy‐confirmed” AD. The consistency of results increases confidence in estimates and suggests consistent case ascertainment over 8 years. Lifetime risk estimates to age 88 for the combined sample (23.4% ± 3.0%) do not approach the 50% risk compatible with an autosomal dominant model of transmission. These results support our previous finding and suggest that an autosomal dominant gene(s) is not responsible for all cases of AD.